TREM2-IN-1 FOR DUMMIES

Minimal concentrations of S1P are chemotactic for osteoclast precursors, even though substantial concentrations inhibit their movement 79. This means that these precursors, which express equally S1PR1 and S1PR2, are held within the vicinity from the bone by the S1P gradient: S1PR2 stops S1PR1-induced migration of those bone-resorbing cells far from